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8 must-read COVID-19 RCTs in NEJM

Efficacy of Tocilizumab in Patients Hospitalized with Covid-19Conclusions: Tocilizumab was not effective for preventing intubation or death in moderately ill hospitalized patients with Covid-19. Some benefit or harm cannot be ruled out, however, because the confidence intervals for efficacy comparisons…

Relative importance of predictors of survival in OHCA

Al-Dury N, Ravn-Fischer A, Hollenberg J, et al. Identifying the relative importance of predictors of survival in out of hospital cardiac arrest: a machine learning study. Scand J Trauma Resusc Emerg Med. 2020;28(1):60. Published 2020 Jun 25. doi:10.1186/s13049-020-00742-9 Overall population The…

Cardiac involvement in COVID-19 patients

Definition of cardiac involvement in COVID19 is challenging: SARS-CoV-2 infection has multifaceted effects From a clinical point of view, cardiac involvement during COVID19 may present a wide spectrum of severity, ranging from subclinical myocardial injury to well-defined clinical entities Three…

Level of Evidence

Level of Evidence A Data derived from multiple randomized clinical trials or meta-analyses of such studies. Level of Evidence B Level of Evidence B-R: Data derived from one or more randomized trials or meta-analysis of such studies. Level of Evidence B-NR: Data…

Classification of Recommendations

Class I: Benefit >>> Risk Conditions for which there is evidence and/or general agreement that a given procedure or treatment is beneficial, useful, and effective. Class II: Conditions for which there is conflicting evidence and/or a divergence of opinion about…

Care after cardiac arrest

Targeted Temperature Management (TTM) 26 RCTs from 2002 to 2019 + TTM2 ongoing and HYPERION trial to be released soon Following 2 RCTs in 2002 (Bernard et al + HACA) the use of TTM T32-34C became widespread Improves neurologically intact…